Semaglutide tolerance

[ltts]

Hello everyone, first post in this forum

I've been on semaglutide for a year now, starting from 0.5mg weekly to 2.5mg weekly after month 6 until now. I've noticed that the appetite-suppressing effect has been getting weaker, and my cravings are starting to come back — whereas before, I had no desire to snack at all.

Has anyone tried to take a few weeks break to help reset or at least reduce tolerance? Or maybe should I just switch to another compound like tirzepatide or retatrutide, but I'm afraid I might develop the same tolerance again, and possibly even faster, since my body is already used to semaglutide.

 

[SalvatoreCorvus]

Tolerance is real.

Psychological first because you get used to a certain level of effect (so the first times when it was stronger seem weak to you now)

But also inside your brain / body and the signals that semaglutide sends (to put it simply as an explanation)

Taking a break is the first really good strategy. 4 weeks minimum before resuming a lower dose, to gradually increase the dose again.

If nothing satisfies you after that, tirz or reta can be more beneficial.
Because it also stimulates other receptors linked to hunger and digestion.
It doesn't necessarily make them stronger. But more versatile in the long term. Especially since we each respond differently to GLP1/glucagon/GIP signal.

And of course... Products aren't everything. Work on yourself and your relationship with food.

 

[ltts]

Thanks a lot for your answer. That confirms my thoughts and will probably take a 1-2month break.

 

[Bigpat]

Hi, I have quite a bit of experience with GLP1s, tolerance is indeed real, with semaglutide I’d be careful going above 2mg a week as the side effects can begin to stack.

For myself I found that alternating between semaglutide and other compounds helps a bit, for example, 2 weeks sema, 2 weeks tirze etc, or even stacking them with an alternating schedule.

I couldn’t find much supporting this in terms of data other than anecdotal evidence, it might as well be placebo effect, as hunger drive is deeply intertwined with psychology, but it worked pretty well for me.

Best of luck!

 

[Einherjar]

In fact, I've heard similar feedback about tolerance. It's no coincidence that the official instructions for Ozempic suggest a gradual increase in dosage from 0.25 to 2.4 mg.

However, I strongly believe that GLP-1 receptor agonists should be part of a comprehensive fat-burning regimen rather than the sole focus. Therefore, I consider semaglutide to be a temporary boost that provides additional results without overtaxing the central nervous system or relying solely on willpower. However, it is recommended to avoid using it for an extended period. This is tool for self motivation boost.