What Is Long-Acting Growth Hormone?🤓🔥

[lisanovskyi]

Growth hormone (GH), also known as human growth hormone (HGH) or somatropin, is a naturally occurring hormone produced by the pituitary gland. In medicine, it’s used to treat growth hormone deficiency in both children and adults. In sports and bodybuilding, it is often (illegally) used for muscle growth, fat loss, and anti-aging purposes.


Standard (Daily) HGH

The most commonly used form of HGH is recombinant somatropin. This version mimics natural human growth hormone and is typically administered via daily injections.

• Half-life: ~3–4 hours
• Brands: Genotropin, Norditropin, Saizen, Jintropin, Ansomone, etc.
• Dosing: Often injected once or twice per day, depending on the goal (medical vs. performance enhancement).

However, the short half-life requires frequent injections to maintain stable levels of IGF-1 (Insulin-like Growth Factor 1), which is responsible for many of GH’s benefits.


What Is Long-Acting HGH (Prolonged Release GH)?

Long-acting growth hormone formulations are modified versions of somatropin, designed to be injected only once a week (or even less frequently in the future).

These formulations are altered to slow down their release into the bloodstream, creating a more stable and sustained effect on IGF-1 levels.


How Does It Work?

Pharmaceutical companies use advanced techniques such as:

• (adding polyethylene glycol)
• Albumin-binding technology
• Pro-drug linkers

These modifications prolong the hormone’s circulation time in the body.


Examples of Long-Acting HGH Products:

Brand Name​	Active Ingredient​	Frequency​	Approved Use​
SogroyaВ®	Somapacitan	1Г— per week	Adults with GH deficiency
SkytrofaВ®	Lonapegsomatropin	1Г— per week	Pediatric use (children with GHD)

These drugs have been approved in the US and Europe for specific medical indications and are showing promising results.




Benefits of Long-Acting HGH:

• Fewer injections – More convenient for patients.
• Improved adherence – Easier to follow long-term.
• Stable IGF-1 levels – Reduced hormonal fluctuation.
• Suitable for both children and adults with GH deficiency.

Drawbacks:

• Higher cost – These formulations are often more expensive.
• Less dosing flexibility – You can’t easily adjust weekly doses.
• Limited availability – Not yet widespread outside of prescription use.

Long-Acting HGH in Sports and Bodybuilding:

• Currently, standard daily somatropin is the most used form in sports circles due to availability and flexibility.
• Long-acting versions like Sogroya or Skytrofa are rarely seen in underground markets and are difficult to find without a prescription.
• These products are intended strictly for medical use.

Summary:

• Long-acting HGH (Somapacitan, Lonapegsomatropin) is a modern innovation offering the benefits of growth hormone with fewer injections.
• They provide a more stable and convenient therapy for those with GH deficiency.
• While promising for medical use, they are currently not common in sports enhancement due to price and access.
• Standard daily somatropin still dominates the athletic and bodybuilding world.

Video link

 

[dr. Doping]

The most commonly used form of HGH is recombinant somatropin. This version mimics natural human growth hormone and is typically administered via daily injections.

• Half-life: ~3–4 hours

Even though half life is relatively short, the time it takes for GH administered subcutaneously to reach peak concentration in the blood is atleast a few hours so once per day dosing is still totally fine.

However, the short half-life requires frequent injections to maintain stable levels of IGF-1 (Insulin-like Growth Factor 1), which is responsible for many of GH’s benefits.

No, that's just wrong. We know IGF1 pulses from GH last more than 24 hours.

Pharmaceutical companies use advanced techniques such as:

• (adding polyethylene glycol)
• Albumin-binding technology
• Pro-drug linkers

Avoid polyethylene glycol additives like the plague, they are quite toxic.
Also, Ngenla, the most prominent long acting GH is using actually created by sticking an HCG peptide onto the GH peptide.

Your post sounds/looks like ChatGPT wrote it.

 

[lisanovskyi]

Even though half life is relatively short, the time it takes for GH administered subcutaneously to reach peak concentration in the blood is atleast a few hours so once per day dosing is still totally fine.

No, that's just wrong. We know IGF1 pulses from GH last more than 24 hours.

Avoid polyethylene glycol additives like the plague, they are quite toxic.
Also, Ngenla, the most prominent long acting GH is using actually created by sticking an HCG peptide onto the GH peptide.

Your post sounds/looks like ChatGPT wrote it.

 

[dr. Doping]

If you are so knowledgable as you clam, atleast write what you're quoting. I despise Dave Palumbo for the brosciency advice he is giving. Go check what Chase Irons, Kurt Havens and other people with actual academic knowledge on the topic have to say.

 

[lisanovskyi]

I provided the link from the bottom, and I even know this person personally

 

[dr. Doping]

I provided the link from the bottom, and I even know this person personally

Chase Irons did a better video with more info and his insight from his own experience with it

 

[Einherjar]

I don't like the idea that blood sugar will be elevated for a long time because the growth hormone is prolonged.

 

[dr. Doping]

I don't like the idea that blood sugar will be elevated for a long time because the growth hormone is prolonged.

It seems that regular GH solves that problem by injectiong it in one bolus dose right before bed. By the time it reaches peak concentration, the glucose spike from the last meal will already be over.

 

[Einherjar]

It seems that regular GH solves that problem by injectiong it in one bolus dose right before bed. By the time it reaches peak concentration, the glucose spike from the last meal will already be over.

Yep, I do an injection before going to bed each day. It seems to me quite logical.