In the FIRST PART of the article we observed the question of when to expect the effect of hormone injections, in the second part we will look at when the effects of dietary supplements occur and how to expect them correctly.

When the dietary supplement will start working is an important and often overlooked point, especially when it comes to supplements with a real physiological effect, and not just a symptomatic effect.
Let's look at a few examples:
The effect of Acetyl - L-carnitine(ALCAR) on fat burning:
It is considered to be a weakly effective dietary supplement that has an unexpressed effect, next to the same caffeine, or God forbid, clenbuterol (which is not a dietary supplement at all, but here for comparison)
However - let's think about how L-carnitine works in general? You take a pill like pressing a button, and the fat will start to melt? In a fairy tale, maybe this works)))
To shift metabolism towards fat burning, you need not just to take carnitine, but to increase mitochondrial activity, activate beta-oxidation, which requires regular intake for 2-4 weeks + physical activity.
The role of L-carnitine is to transport fatty acids to the mitochondria. This transport makes sense if the mitochondria actins - that is, you do cardio or high-intensity training with the required duration.
Below is a table of scientifically proven effects of Acetyl - L-carnitine broken down by time:
For weight loss and improved fat metabolism, the first subjective increases in energy may appear after 1-2 weeks, and the first visible changes after 4-6 weeks of regular intake along with physical activity
Thus, the first biochemical and subjective effects of L-carnitine can be expected in a period of several days to 2 weeks, and stable and noticeable physiological changes after 4-6 weeks or more. The maximum clinical effect is often achieved after 8-12 weeks of continuous intake.
If we are talking about more complex effects, such as those that adaptogens have on cortisol and chronic stress, it is worth repeating that cortisol appears as a result of long-term stress, it is like a more prolonged version of adrenaline, a way of adapting to long-term adverse conditions, when adrenaline would simply burn you out, cortisol helps to evenly distribute the stress load.
Accordingly, the overproduction of cortisol is a consequence of long-term influence, and it would be very traumatic to instantly stop this huge cascade of reactions to produce cortisol. Thus, studies confirm that adaptogens such as ashwagandha (Withania somnifera) are able to modulate the hypothalamic-pituitary-adrenal axis (HPA axis), reduce cortisol levels and improve the body's adaptation to stress: taking ashwagandha extract (for example, 300 mg twice a day) in people with high stress levels leads to a reliable decrease in serum cortisol and a decrease in scores on stress scales after 2-3 weeks of daily intake. Significant differences between the groups were noted after 60 days, which corresponds to the time frame for the formation of the adaptive effect through the gradual regulation of receptors and hormonal synthesis
A noticeable clinical effect usually occurs with a course of intake from 1 to 3 weeks, and a stable improvement - after 6-8 weeks. [8]
The next study assessed the subjects' anxiety using the Hamilton scale, and the effect on their condition of taking a standardized extract of Ashwagandha (and the most recognized of the standardized ones, KSM-66, you can find in AllAES capsules).
And as you can see from the graph below, noticeable effects were noted after 30 days, and then after 60 days.[9]

Since the mechanisms of action include receptor regulation, modulation of stress protein expression, and normalization of hormonal balance, they simply cannot work quickly.
And as proof, a systematic review and meta-analysis of 12 randomized controlled trials involving 1,002 participants aged 25 to 48 years showed that taking ashwagandha in people with stress significantly reduces cortisol levels. Most studies observed a decrease in cortisol after 30 days, with the maximum effect occurring after 60–112 days of use. A positive effect on stress was noted in all analyzed RCTs, with no side effects. [10]
Conclusion:
Changes associated with the systematic effects of both hormones, such as testosterone, and dietary supplements, such as L-carnitine and Ashwagada, are not instantaneous.
Processes such as obesity, testosterone deficiency (and all the secondary effects of this deficiency, including low libido and decreased muscle mass) develop over years, and expecting one pill to produce instant changes is foolish.
The clinical effects of both supplements and hormones have been proven and are statistically significant, scientific studies show changes in the condition and body composition of the participants in the experiments, but all these changes require time and disciplined use, which many supplement users prefer to ignore.
The effect of using supplements can be compared to ballistic scemes, where the slightest changes in the angle of the barrel, caliber or powder charge can change the impact location of the projectile by kilometers.

You should not think that you will start taking the drug today, and the effect will be tomorrow. It is worth thinking that if you DO NOT start taking the drug today, then in 60 days, you will remain at the same point where you were.
Only prohibited substances have an immediate effect, the purchase and sale of which is subject to severe punishment. Allaes is a safer and healthier way to change your life easily, folks
P.S. Ashwagandha is banned in Russia and restricted for sale in some European countries.
In 2021, Russian helath ministry included ashwagandha in the list of plants containing pharmacologically active substances. The reason is the potential adaptogenic, hormonally active and psychotropic effect because it affects the central nervous system (like ginseng, eleutherococcus, etc.), and can also modulate hormonal levels (for example, cortisol, testosterone), and it also has a pronounced calming effect that is felt already at the first intake - for them this is a reason to ban Ashwagandha, and for us an excellent reason to pay attention to it!
In general, buy boldly - Standardized extract of Ashwagandha KSM-66 then Allaes is what you need to feel great! Sicence proven

[1] https://pubmed.ncbi.nlm.nih.gov/21701126/
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC6343764/
[3] https://sunm.edu/when-to-take-l-carnitine/
[4] https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/
[5] https://researchoutput.csu.edu.au/ws/portalfiles/portal/8804580/Cao Y L-Carnitine TJEM.pdf
[6] https://www.liebertpub.com/doi/abs/10.1089/ars.2006.8.404?journalCode=ars
[7] https://pubmed.ncbi.nlm.nih.gov/7908343/
[8] https://onlinelibrary.wiley.com/doi/10.1002/ptr.7598
[9] https://brainperform.de/wp-content/uploads/2018/11/withania_review.pdf
[10] https://pmc.ncbi.nlm.nih.gov/articles/PMC10745833/

When the dietary supplement will start working is an important and often overlooked point, especially when it comes to supplements with a real physiological effect, and not just a symptomatic effect.
Let's look at a few examples:
The effect of Acetyl - L-carnitine(ALCAR) on fat burning:
It is considered to be a weakly effective dietary supplement that has an unexpressed effect, next to the same caffeine, or God forbid, clenbuterol (which is not a dietary supplement at all, but here for comparison)
However - let's think about how L-carnitine works in general? You take a pill like pressing a button, and the fat will start to melt? In a fairy tale, maybe this works)))
To shift metabolism towards fat burning, you need not just to take carnitine, but to increase mitochondrial activity, activate beta-oxidation, which requires regular intake for 2-4 weeks + physical activity.
The role of L-carnitine is to transport fatty acids to the mitochondria. This transport makes sense if the mitochondria actins - that is, you do cardio or high-intensity training with the required duration.
Below is a table of scientifically proven effects of Acetyl - L-carnitine broken down by time:
Timeframe | Observed Effects |
---|---|
3–4 days | Initial improvements in mental energy and antioxidant activity begin to emerge — particularly noticeable with acetyl-L-carnitine (ALCAR). Even a single dose can boost key antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase, with peak effects occurring around 3.5 hours after ingestion. [1][5] |
1–2 weeks | Noticeable increase in energy levels, mild enhancement of endurance, and reduction in lactate-induced fatigue during exercise. [2] |
3–6 weeks | First significant physical changes become apparent: decreased fat mass, improved exercise performance, enhanced recovery, reduced muscle soreness, and an overall boost in well-being. [3] |
6–9 weeks | Strength gains are observed, alongside further improvements in endurance and a reduction in lactic acid accumulation during physical activity. |
Up to 12 weeks (≈3 months) | Substantial improvements in physical performance, reductions in fatigue symptoms, and support for cardiovascular and metabolic function, especially when taken consistently. [4] Athletes and active individuals may experience enhanced VO₂max, reduced lactate levels, and faster muscle recovery over this period. |
4 months and beyond | Long-term use stimulates endogenous brain antioxidant defense systems — including heme oxygenase-1, heat shock proteins (Hsp70), and mitochondrial SOD-2 — contributing to better mitochondrial function and neuroprotection. In cell models, chronic exposure to ALCAR reduces neuronal death and oxidative stress, demonstrating lasting cellular protection over extended periods. [6][7] |
For weight loss and improved fat metabolism, the first subjective increases in energy may appear after 1-2 weeks, and the first visible changes after 4-6 weeks of regular intake along with physical activity
Thus, the first biochemical and subjective effects of L-carnitine can be expected in a period of several days to 2 weeks, and stable and noticeable physiological changes after 4-6 weeks or more. The maximum clinical effect is often achieved after 8-12 weeks of continuous intake.
If we are talking about more complex effects, such as those that adaptogens have on cortisol and chronic stress, it is worth repeating that cortisol appears as a result of long-term stress, it is like a more prolonged version of adrenaline, a way of adapting to long-term adverse conditions, when adrenaline would simply burn you out, cortisol helps to evenly distribute the stress load.
Accordingly, the overproduction of cortisol is a consequence of long-term influence, and it would be very traumatic to instantly stop this huge cascade of reactions to produce cortisol. Thus, studies confirm that adaptogens such as ashwagandha (Withania somnifera) are able to modulate the hypothalamic-pituitary-adrenal axis (HPA axis), reduce cortisol levels and improve the body's adaptation to stress: taking ashwagandha extract (for example, 300 mg twice a day) in people with high stress levels leads to a reliable decrease in serum cortisol and a decrease in scores on stress scales after 2-3 weeks of daily intake. Significant differences between the groups were noted after 60 days, which corresponds to the time frame for the formation of the adaptive effect through the gradual regulation of receptors and hormonal synthesis
A noticeable clinical effect usually occurs with a course of intake from 1 to 3 weeks, and a stable improvement - after 6-8 weeks. [8]
The next study assessed the subjects' anxiety using the Hamilton scale, and the effect on their condition of taking a standardized extract of Ashwagandha (and the most recognized of the standardized ones, KSM-66, you can find in AllAES capsules).
And as you can see from the graph below, noticeable effects were noted after 30 days, and then after 60 days.[9]

Since the mechanisms of action include receptor regulation, modulation of stress protein expression, and normalization of hormonal balance, they simply cannot work quickly.
And as proof, a systematic review and meta-analysis of 12 randomized controlled trials involving 1,002 participants aged 25 to 48 years showed that taking ashwagandha in people with stress significantly reduces cortisol levels. Most studies observed a decrease in cortisol after 30 days, with the maximum effect occurring after 60–112 days of use. A positive effect on stress was noted in all analyzed RCTs, with no side effects. [10]
Conclusion:
Changes associated with the systematic effects of both hormones, such as testosterone, and dietary supplements, such as L-carnitine and Ashwagada, are not instantaneous.
Processes such as obesity, testosterone deficiency (and all the secondary effects of this deficiency, including low libido and decreased muscle mass) develop over years, and expecting one pill to produce instant changes is foolish.
The clinical effects of both supplements and hormones have been proven and are statistically significant, scientific studies show changes in the condition and body composition of the participants in the experiments, but all these changes require time and disciplined use, which many supplement users prefer to ignore.
The effect of using supplements can be compared to ballistic scemes, where the slightest changes in the angle of the barrel, caliber or powder charge can change the impact location of the projectile by kilometers.

You should not think that you will start taking the drug today, and the effect will be tomorrow. It is worth thinking that if you DO NOT start taking the drug today, then in 60 days, you will remain at the same point where you were.
Only prohibited substances have an immediate effect, the purchase and sale of which is subject to severe punishment. Allaes is a safer and healthier way to change your life easily, folks
P.S. Ashwagandha is banned in Russia and restricted for sale in some European countries.
In 2021, Russian helath ministry included ashwagandha in the list of plants containing pharmacologically active substances. The reason is the potential adaptogenic, hormonally active and psychotropic effect because it affects the central nervous system (like ginseng, eleutherococcus, etc.), and can also modulate hormonal levels (for example, cortisol, testosterone), and it also has a pronounced calming effect that is felt already at the first intake - for them this is a reason to ban Ashwagandha, and for us an excellent reason to pay attention to it!
In general, buy boldly - Standardized extract of Ashwagandha KSM-66 then Allaes is what you need to feel great! Sicence proven

[1] https://pubmed.ncbi.nlm.nih.gov/21701126/
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC6343764/
[3] https://sunm.edu/when-to-take-l-carnitine/
[4] https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/
[5] https://researchoutput.csu.edu.au/ws/portalfiles/portal/8804580/Cao Y L-Carnitine TJEM.pdf
[6] https://www.liebertpub.com/doi/abs/10.1089/ars.2006.8.404?journalCode=ars
[7] https://pubmed.ncbi.nlm.nih.gov/7908343/
[8] https://onlinelibrary.wiley.com/doi/10.1002/ptr.7598
[9] https://brainperform.de/wp-content/uploads/2018/11/withania_review.pdf
[10] https://pmc.ncbi.nlm.nih.gov/articles/PMC10745833/
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