Enclomiphene Cycle

[Bubbler]

Hi, I’d like to share my experience with Enclomiphene from Driada.

I started taking Enclomiphene on January 3rd, 2026.

My bloodwork before using Enclomiphene:

Total Testosterone: 646 ng/dL
Free Testosterone: 106 pg/mL
SHBG: 48 nmol/L
Albumin: 4.8 g/dL

I spent a lot of time researching dosing protocols and intervals. In studies, doses ranged from 12.5 mg to 25 mg daily. For a PCT, I would probably follow a similar schedule, but if you just want to improve your baseline testosterone, that approach can quickly cause issues.
Many users report libido crashes and mental discomfort. That likely comes from the effects of chronically low estrogen levels in the brain (at least according to current theories).
Because of that, many users switched to different dosing intervals - anywhere from 6.25 mg every other day or 12.5 mg every third day, to 12.5 mg once a week.
I decided to go with 12.5 mg every third day.

I can’t report anything too dramatic so far since the effects are quite subtle - but still noticeable if you pay attention and know how you felt before.
Even though my baseline numbers looked decent at first glance, my free testosterone wasn’t in a good range because of high SHBG. I tried everything to lower it - Tongkat Ali, 10 mg boron, 50 mg zinc - but it stayed high.
As a result, I had symptoms of low testosterone: low energy no matter how much I slept, declining strength in the gym, muscle loss despite training, mood swings...
All of that has gone away since I started taking Enclomiphene, and I keep feeling better overall.

Blood results from January 19th:

Total Testosterone: 1344 ng/dL
Free Testosterone: 145 pg/mL
SHBG: 100 nmol/L
Estrogen: 21.5 pg/mL

As you can see - clear improvements, and I can feel them too.
However, my SHBG is extremely high, and I’m not quite sure what to do about it. I even had dumb thoughts like maybe taking a low-dose Anavar cycle for a short time, but that’s obviously not a sustainable approach.

Overall, I’m really satisfied with the results. If you have any feedback, suggestions, or tips, I’d be happy to hear them

 

[Donvitosharkone]

Hi, I’d like to share my experience with Enclomiphene from Driada.

I started taking Enclomiphene on January 3rd, 2026.

My bloodwork before using Enclomiphene:

Total Testosterone: 646 ng/dL
Free Testosterone: 106 pg/mL
SHBG: 48 nmol/L
Albumin: 4.8 g/dL

I spent a lot of time researching dosing protocols and intervals. In studies, doses ranged from 12.5 mg to 25 mg daily. For a PCT, I would probably follow a similar schedule, but if you just want to improve your baseline testosterone, that approach can quickly cause issues.
Many users report libido crashes and mental discomfort. That likely comes from the effects of chronically low estrogen levels in the brain (at least according to current theories).
Because of that, many users switched to different dosing intervals - anywhere from 6.25 mg every other day or 12.5 mg every third day, to 12.5 mg once a week.
I decided to go with 12.5 mg every third day.

I can’t report anything too dramatic so far since the effects are quite subtle - but still noticeable if you pay attention and know how you felt before.
Even though my baseline numbers looked decent at first glance, my free testosterone wasn’t in a good range because of high SHBG. I tried everything to lower it - Tongkat Ali, 10 mg boron, 50 mg zinc - but it stayed high.
As a result, I had symptoms of low testosterone: low energy no matter how much I slept, declining strength in the gym, muscle loss despite training, mood swings...
All of that has gone away since I started taking Enclomiphene, and I keep feeling better overall.

Blood results from January 19th:

Total Testosterone: 1344 ng/dL
Free Testosterone: 145 pg/mL
SHBG: 100 nmol/L
Estrogen: 21.5 pg/mL

As you can see - clear improvements, and I can feel them too.
However, my SHBG is extremely high, and I’m not quite sure what to do about it. I even had dumb thoughts like maybe taking a low-dose Anavar cycle for a short time, but that’s obviously not a sustainable approach.

Overall, I’m really satisfied with the results. If you have any feedback, suggestions, or tips, I’d be happy to hear them

Thanks for sharing such a detailed write-up, this is actually a very useful post, especially because you included pre and post bloodwork and not just subjective feelings.

A few points stand out clearly :

First, your approach to dosing makes sense. Enclomiphene is one of those compounds where daily dosing can easily overshoot what the brain actually tolerates well, especially long term. The libido and mental sides people report are very consistent with relative estrogen deprivation at the CNS level, even if serum estradiol doesn’t look critically low on paper. Using a spaced protocol like 12.5 mg every third day is a much more conservative and sustainable way to assess response.

Second, the improvement in symptoms is the most important signal here. Numbers are useful, but the fact that fatigue, strength regression, mood instability, and muscle loss resolved suggests that, functionally, you were under-androgenized despite “okay-looking” total testosterone before. High SHBG masking low bioavailable androgens is a very real issue, and your case illustrates that well.

That said, your follow-up labs also highlight the main trade-off: SHBG doubling to 100 nmol/L is not trivial. Enclomiphene often increases SHBG further because of its estrogenic signaling at the liver, so seeing total T go up strongly while free T rises only modestly is a pattern we see quite often. This is also why chasing total testosterone alone can be misleading with SERMs.

I’m glad you immediately dismissed the idea of using something like Anavar to “fix” SHBG. That would work on paper, but it’s exactly the kind of short-term patch that creates a new problem instead of solving the original one.

At this stage, I’d personally be cautious about drawing long-term conclusions at just over two weeks. Enclomiphene tends to look great early, and then the balance between androgen signaling, estrogen signaling, and SHBG sometimes shifts again after a few more weeks. Monitoring trends matters more than single snapshots.

If you continue, I’d strongly suggest:

• Rechecking labs after 4–6 weeks on the same protocol, not increasing dose.
• Keeping an eye on symptoms more than numbers, especially libido, sleep quality, mood stability, and training performance.
• Looking beyond hormones for SHBG drivers as well: caloric intake, carbohydrate availability, thyroid status, liver markers, and overall stress load all matter here.

Overall, this is a solid, thoughtful experiment, and your dosing restraint is refreshing to see. Just be careful not to turn a clearly beneficial short-term response into a long-term protocol without confirming that the system actually stabilizes rather than compensates against you.

Shark