GLP agonists big difference

[Broccoliwithchicken]

So about the glp medications used for weight loss, how big is the difference between the 3?
Positives but also side effects. Also very curious about the dopamine factor, lots of talk about people getting depressed on it but also about it beeing researched to help people fight addictions.
Looking for some anecdotal experiences, thanks for sharing!

 

[ChemX]

Currently on semaglutide (haven’t tried all three), and I noticed it reduce in pleasure, but in a weird way. Not really depression, more like everything just feels less enjoyable.

I’m still hungry, but I end up chasing foods I might enjoy a little, rather than just eating clean. It definitely helps with weight loss, but also can lead to muscle loss, because smaller protein intake.

Side effects are there, but if you microdose and slowly increase, they can be minimal.

Funny thing is, I noticed all this before I even knew GLP-1s affect dopamine. I haven’t researched the science in depth, but based on how I feel. There’s definitely something there.
Kinda had a little lower sex drive at the beginning of my max dose. But I still love sex, but apparently little less than usual. Still smoking, just not enjoying as i did before Semaglutide.
Stimulants ,they "kick", just in a weirder way.
Nothing drastic, but it definitely does something with dopamine.

I’ve heard it’s being tested for addiction and OCD.

 

[Bigpat]

So about the glp medications used for weight loss, how big is the difference between the 3?
Positives but also side effects. Also very curious about the dopamine factor, lots of talk about people getting depressed on it but also about it beeing researched to help people fight addictions.
Looking for some anecdotal experiences, thanks for sharing!
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Hi I’ve tried all three (sema, Reta, tirze, I wanna say that in terms of psychological effect there isn’t a huge difference, but in terms of physical effect ( hunger suppression) there definitely is a difference in potency.

In my experience tirzepatide definitely suppresses hunger more effectively than semaglutide and retatrutide, with this last one also allegedly having an effect on BMR, so the long term effects as a fat burner will be more marked.

In general, like I was saying in another thread, I haven’t found a lot of evidence on this, but it seems at least to me like rotating the compounds might actually mitigate developed tolerance, for example switching back and forth from semaglutide and tirzepatide once the maximum safe dosage is reached
(2.5mg for semaglutide and 10mg for tirzepatide).

As for side effects, I haven’t really had many other than some bloating initially, always tolerated them all pretty well.
Though I did notice it does indeed take a lot of pleasure out of eating, but one might argue that’s more a wanted effect rather than a side effect.

 

[Baugaros]

I've been taking 1mg of Semaglutide for 8 weeks now and have had no problems. I started with 0.5-0.50-1mg.

The first few weeks, you do seem more subdued, but I attribute that to the fact that you've significantly reduced your food intake, and it shows... 12kg in 3 months.

 

[dr. Doping]

It definitely helps with weight loss, but also can lead to muscle loss, because smaller protein intake.
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The studies that show this are the ones where it's actually important to point out they're done on the general population (I call them FDA approved people - 135lbs males, that sit all day, drink 1,5L of water, barely move, eat like shit and sleep like shit). If you're on anabolics, take care of your protein intake and train, I really doubt you'd lose anymore muscle than you would without taking them, but dieting all the same.

 

[ChemX]

The studies that show this are the ones where it's actually important to point out they're done on the general population (I call them FDA approved people - 135lbs males, that sit all day, drink 1,5L of water, barely move, eat like shit and sleep like shit). If you're on anabolics, take care of your protein intake and train, I really doubt you'd lose anymore muscle than you would without taking them, but dieting all the same.

""FDA approved people" that's a nice term. I agree 100%. Definitely the wrong people to show the data of results.
Most (if not everyone) here know how to diet, and either way, you should up the protein intake during a cut. It helps preserve muscle mass, protein gives the most satiety out of all macros, etc.
Just saying, I did notice that protein intake can be harder. I did multiple cuts without GLP-1 and now with semaglutide (of course, if you're doing AAS, you should know how much protein you need, and you should be good then), and now I'm on semaglutide so I can feel the difference.
It's not that significant like they claim in studies, but I did notice that while I was adapting to the dose, I felt a bit weaker. Probably because of glucose levels. It was a new substance for the body.
But with time you get used to it, and it's a great tool if you know what you're doing. Not like the "FDA approved people"

 

[Falcon]

I see many people have used these here, and also Reddit is full of satisfied users. Everyone seems to recommend these over repartitioning agents (which is basically clenbuterol as far as I know, let's just leave dnp out of the picture). Am I right to believe that they mostly work by just reducing appetite and slightly improving insulin sensitivity, but have no repartitioning effect? Whenever someone mentions clenbuterol, people jump on them in Reddit telling them to use GLP substances instead. But don't these simply make you eat less, instead of improving partitioning and thermogenesis? Are they worth to use if someone is barely hungry in the first place?

 

[dr. Doping]

I see many people have used these here, and also Reddit is full of satisfied users. Everyone seems to recommend these over repartitioning agents (which is basically clenbuterol as far as I know, let's just leave dnp out of the picture). Am I right to believe that they mostly work by just reducing appetite and slightly improving insulin sensitivity, but have no repartitioning effect? Whenever someone mentions clenbuterol, people jump on them in Reddit telling them to use GLP substances instead. But don't these simply make you eat less, instead of improving partitioning and thermogenesis? Are they worth to use if someone is barely hungry in the first place?

As far as I know, only retatrutide at around 4mg per week (or higher) has an actual fat burning effect, all other options (sema, tirz and lower dose reta) are just apetite supressants. More important question is whether you need a thermogenic or a partitioning drug.

 

[Falcon]

As far as I know, only retatrutide at around 4mg per week (or higher) has an actual fat burning effect, all other options (sema, tirz and lower dose reta) are just apetite supressants. More important question is whether you need a thermogenic or a partitioning drug.

What about needing both? The only ones I know about are clenbuterol (and dnp and cardarine which seem more dangerous, although the verdict is still out on clenbuterol and cardarine, but the latter has never been tested on humans long enough). Are there others? I've read that MOTS-C may also regulate / fix metabolism, but the mechanism is not yet clear to me. And I'm vary about substances that haven't been around long enough. Berberine also seems to be a good option for metabolism. Oh, and there is HGH as well. I'm not sure about the magnitude of the effects though. I've read around whatever I could find, and it seems not conclusive.

 

[dr. Doping]

What about needing both? The only ones I know about are clenbuterol (and dnp and cardarine which seem more dangerous, although the verdict is still out on clenbuterol and cardarine, but the latter has never been tested on humans long enough). Are there others? I've read that MOTS-C may also regulate / fix metabolism, but the mechanism is not yet clear to me. And I'm vary about substances that haven't been around long enough. Berberine also seems to be a good option for metabolism. Oh, and there is HGH as well. I'm not sure about the magnitude of the effects though. I've read around whatever I could find, and it seems not conclusive.

GH and IGF1 would be the first ones that come to my mind. And even though this might be anecdotal, I feel like 4ius of GH have a crazy effect on my body composition. When I start my cut next February, I can't wait to see how GH works on a cut. But as far as fat burners go, what is your current situation and why do you believe it warrants using them?