Expert Answered HGH- Persistent whole-body paresthesia (pins and needles) triggered by exertion/stress while on GH and Test

[ameerahmada28]

Hi everyone,

I’m posting to share an issue I’ve been experiencing lately and would greatly appreciate any insights, technical thoughts, or similar experiences.

Context & Protocol:

• GH: 4 IU daily, taken in the morning (used for approximately 2 months).
• Testosterone: 600 mg per week, split into two doses, I’ve been using test for 3 years in many cycles with pcts in between.
• Body Composition Response: Noticeably, I have observed no apparent fat loss during this 2-month period.

The Issues:

1. Paresthesia: Over the past month, I have gradually developed a persistent "pins and needles" or tingling sensation across all of my body. The symptoms appear to be explicitly triggered or severely aggravated by physical exertion or muscle tension (making even low-intensity workouts difficult), laughing, or stress.
2. Temperature-Triggered Bumps: I’ve also noticed that skin bumps/pimples tend to appear whenever my body temperature rises, and they quickly subside or disappear once I cool down or take a cold shower.

Progression & Actions Taken: The tingling has progressively worsened. Yesterday, the symptoms were severe enough to noticeably interfere with my normal daily work and completely halt my training session.

Has anyone experienced similar nerve or skin side effects from GH or test, and what steps were effective in resolving it?

Any physiological explanations or recommendations would be very welcome. Thank you in advance.

 

[Donvitosharkone]

Hi everyone,

I’m posting to share an issue I’ve been experiencing lately and would greatly appreciate any insights, technical thoughts, or similar experiences.

Context & Protocol:

• GH: 4 IU daily, taken in the morning (used for approximately 2 months).
• Testosterone: 600 mg per week, split into two doses, I’ve been using test for 3 years in many cycles with pcts in between.
• Body Composition Response: Noticeably, I have observed no apparent fat loss during this 2-month period.

The Issues:

1. Paresthesia: Over the past month, I have gradually developed a persistent "pins and needles" or tingling sensation across all of my body. The symptoms appear to be explicitly triggered or severely aggravated by physical exertion or muscle tension (making even low-intensity workouts difficult), laughing, or stress.
2. Temperature-Triggered Bumps: I’ve also noticed that skin bumps/pimples tend to appear whenever my body temperature rises, and they quickly subside or disappear once I cool down or take a cold shower.

Progression & Actions Taken: The tingling has progressively worsened. Yesterday, the symptoms were severe enough to noticeably interfere with my normal daily work and completely halt my training session.

Has anyone experienced similar nerve or skin side effects from GH or test, and what steps were effective in resolving it?

Any physiological explanations or recommendations would be very welcome. Thank you in advance.

GH can cause fluid retention and nerve compression, but persistent tingling across your entire body isn’t something I’d automatically blame on HGH.

The bumps appearing when you get hot or exercise could be cholinergic urticaria, a reaction triggered by increased body temperature. But that doesn’t fully explain the worsening tingling.

If this is affecting your daily activities, you should stop the HGH for now and get medically assessed as soon as possible. if you develop breathing difficulties, swelling, weakness or fainting, seek emergency care.

I’d also check blood pressure, glucose, HbA1c, electrolytes and kidney function, and review your testosterone use.

A few questions:

Did the symptoms start only after introducing GH?
Do the bumps itch, burn or look like small hives?
Does the tingling disappear completely when you cool down?
Have you checked your blood pressure and glucose recently?

And I would suggest forgetting about the lack of fat loss for now. Your health comes first, especially when symptoms are getting progressively worse.

Keep us updated after your assessment.

Shark

 

[ameerahmada28]

Hi
Did the symptoms start only after introducing GH?
Yes
Do the bumps itch, burn or look like small hives?
Small hives
Does the tingling disappear completely when you cool down?
Yes 100%
Have you checked your blood pressure and glucose recently?
Pressure increased with GH and tingling

I stopped everything now and just taking HCG for a week then pct

I’m using also medicine for histamine

 

[Sam Bjorn]

Hi
Did the symptoms start only after introducing GH?
Yes
Do the bumps itch, burn or look like small hives?
Small hives
Does the tingling disappear completely when you cool down?
Yes 100%
Have you checked your blood pressure and glucose recently?
Pressure increased with GH and tingling

I stopped everything now and just taking HCG for a week then pct

I’m using also medicine for histamine

Based on your description, it sounds like cholinergic urticaria, but I'm not a doctor, so I can't make a diagnosis.

The symptoms of this type of urticaria occur because of an abnormal skin reaction to an increase in core body temperature and activation of sweating. And that's exactly what triggers an episode — physical activity, stress, laughing, or a hot shower.

But why the condition appeared in the first place is a much more complicated question. In many cases, the exact underlying cause can't be identified. There can be different causes, including stress, of course.

I've had periods in my life when I'd go outside in the summer, walk quickly, start sweating, and then feel a prickling sensation on my face, neck, and back, along with itching. It felt something like the tingling you get after taking beta-alanine. After a while, the itching would go away. I still don't know what caused it.

Have you seen a doctor? Stopping the compounds might not help at all if the cause is something else. To figure it out, you need to see a doctor and start getting it checked out.

 

[ameerahmada28]

Hi
Yes, I went to doctor, and it is cholinergic urticaria.
He could not also precisely confirm the reason of it, as it can be due to stress (which I have been with it recently)
is has been 14 days now after my last intake to HGH, I’m taking medicine for histamine and and the small hives are now less “still occurring “ I attached a photo how it looks like in the worst case now.
I feel my body is comfortable, my sleeping is better and deeper (which shocked me).
I only take HCG and in couple of days I’ll start with Clumid.

The thing, I still have 300 iu of HGH that I don’t know what to do with (definitely not taking them again)

 

[Sam Bjorn]

Hi
Yes, I went to doctor, and it is cholinergic urticaria.
He could not also precisely confirm the reason of it, as it can be due to stress (which I have been with it recently)
is has been 14 days now after my last intake to HGH, I’m taking medicine for histamine and and the small hives are now less “still occurring “ I attached a photo how it looks like in the worst case now.
I feel my body is comfortable, my sleeping is better and deeper (which shocked me).
I only take HCG and in couple of days I’ll start with Clumid.

The thing, I still have 300 iu of HGH that I don’t know what to do with (definitely not taking them again)

The problem with this condition is that the trigger could be something completely different, or more likely, a combination of several factors. Stress in particular can be a catalyst for many reactions like this. And the problem is that doctors often don't look too deeply into these cases or try to find the underlying cause.

It's possible this will never happen to you again. But if it keeps coming back, then it's worth investigating further.

From what I've read about this condition, one of the most important things is determining whether you have cholinergic urticaria with acquired impairment of sweating. There's a specific test for this, and if that's the case, corticosteroids are sometimes used alongside antihistamines. But overall, this condition isn't very well understood.

In some ways, it reminds me of the approach to skin conditions like dermatitis or psoriasis — you have the condition, but identifying what actually triggers it can be almost impossible. And there's no real cure, just ways to manage the symptoms. I know this from personal experience.

You could try getting some blood tests to check certain markers and see if they provide any indirect clues. But the question is whether you want to investigate this further.