- Thread Author
- #281
From your list, only two compounds are clear to me: 5-Amino-1MQ and Tesamorelin.5 amino 1 mq
Sobetirome GC-1
Tesamorelin
Testofensine
Mirabegrone
As for the rest, I don’t really understand why someone would use less-proven compounds when we already have alternatives that are known to work well.
Tesofensine - If I understand correctly, it mainly suppresses appetite. But for that purpose, there is at least sibutramine, which works in a similar way and has been used for a long time. That said, in my opinion, after the rise of GLP-1 agonists, drugs like this should mostly stay in the background. It seems smarter to influence appetite through different mechanisms rather than through neurotransmitter regulation.
Mirabegron - I don’t see much value for athletes here. The fat-loss effect is weak and only provides a small increase in energy expenditure. At doses where you start to see any noticeable effect, the risk of increased heart rate and blood pressure goes up — meaning side effects show up before real benefits. In the end, it doesn’t improve strength, endurance, or body composition enough to justify off-label use. It feels like too little upside for too much risk. Clenbuterol or salbutamol are also higher-risk drugs, but at least they can produce a noticeable effect. Even so, despite their popularity, I believe GLP-1s are both more effective and safer overall. If you disagree, I’d genuinely be interested to hear the arguments.
Sobetirome (GC-1) - The idea is clear: increase metabolism and fat loss while reducing the side effects we get from traditional thyroid hormones by acting more selectively on thyroid receptors. But is it worth using such an under-studied compound when it comes to the thyroid? The long-term impact is not well known. Is it really worth it? In my view, this is one of the riskiest options on the list.
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