Experience With Peptides (BPC-157 & TB-500) Chronic Knee Pain

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Hey everyone,
I’m 23 years old, 6'0" (1.84m), and for over two years I struggled with chronic knee pain. It started after a mountain run when I was around 96 kg (~212 lbs). Ever since that day, I had a constant stabbing pain in my knee (mainly on the inside/medial side). I couldn’t do leg training for months, and even later the pain always came back.
I tried pretty much everything: magnet therapy, cortisone treatments, sauna, stretching, mobility work – nothing brought lasting relief. After two years of this, I finally came across peptides. About two months ago, I decided to give them a try.

BPC-157​

  • Typical dosage: 250–500 mcg per day, split into 1–2 injections
  • Injection method: subcutaneous into the tissue around the joint (never directly inside)
  • Rotation: inject at different spots around the knee to avoid hitting the same area repeatedly
  • Effect: works slowly; on its own I didn’t notice dramatic improvements, but it likely laid the foundation for healing

TB-500​

  • Loading phase: 2–2.5 mg per week (split into multiple injections) for 4–6 weeks
  • Maintenance (optional): 1–2 mg every 1–2 weeks
  • Injection method: subcutaneous or intramuscular (systemic effect, not just local)
  • Effect: after ~2 weeks, pain reduced dramatically and mobility came back

Results​

  • Currently pain-free
  • Can squat and train legs normally again
  • Kept up some sauna, mobility, and stretching work on the side (nothing extreme, but consistent)

Takeaway​

  • BPC-157: slow and subtle, sets the stage for recovery
  • TB-500: the real gamechanger, brought the breakthrough
  • After 2 years of no real progress, I’m finally back to full training without knee pain
 
Man, this log hits home for anyone who’s dealt with nagging joint pain.

Two years of stabbing knee pain is no joke, especially when it takes you out of leg training.

The fact you tried all the standard routes, cortisone, magnet therapy, sauna, mobility and all the sh**ty things but nothing worked shows how brutal chronic injuries can be. Respect for pushing through that long.

The peptide approach here is honestly textbook.

BPC-157 is subtle, like you said, it doesn’t feel dramatic (and does not have to!!) but it lays the groundwork for tissue repair. The way you rotated injections around the joint is exactly how you avoid scar tissue build up and maximize local benefits.

TB-500 on top of that is the golden standard of a real gamechanger. Two weeks in and pain dropping while mobility comes back, that’s the kind of turnaround people hope for but rarely get. The systemic effect of TB-500 makes sense, seems you nailed the dosing right with a proper loading phase before tapering down.

Your results confirms all: pain free, squatting again, and full leg training after two years of stop-and-go. SOOOOO!! That’s not placebo… !

that’s repair in action. Plus, the fact you kept up sauna and mobility alongside peptides shows you built a full environment for healing instead of just hoping for a magic fix.

If there’s one thing I’d suggest:

keeping a closer eye on long-term tendon integrity.

Just because the pain’s gone doesn’t mean the tissue’s bulletproof yet. Gradual load progression and maybe one more short maintenance pulse of TB-500 could help lock in the recovery for good.

Overall, this is one of those comeback stories that shows why peptides deserve more attention in sports medicine. From sidelined and frustrated to training legs again pain-free

it’s the kind of win every lifter with chronic pain dreams about…. Thanks for sharing it!!

Shark!
 
Man, this log hits home for anyone who’s dealt with nagging joint pain.

Two years of stabbing knee pain is no joke, especially when it takes you out of leg training.

The fact you tried all the standard routes, cortisone, magnet therapy, sauna, mobility and all the sh**ty things but nothing worked shows how brutal chronic injuries can be. Respect for pushing through that long.

The peptide approach here is honestly textbook.

BPC-157 is subtle, like you said, it doesn’t feel dramatic (and does not have to!!) but it lays the groundwork for tissue repair. The way you rotated injections around the joint is exactly how you avoid scar tissue build up and maximize local benefits.

TB-500 on top of that is the golden standard of a real gamechanger. Two weeks in and pain dropping while mobility comes back, that’s the kind of turnaround people hope for but rarely get. The systemic effect of TB-500 makes sense, seems you nailed the dosing right with a proper loading phase before tapering down.

Your results confirms all: pain free, squatting again, and full leg training after two years of stop-and-go. SOOOOO!! That’s not placebo… !

that’s repair in action. Plus, the fact you kept up sauna and mobility alongside peptides shows you built a full environment for healing instead of just hoping for a magic fix.

If there’s one thing I’d suggest:

keeping a closer eye on long-term tendon integrity.

Just because the pain’s gone doesn’t mean the tissue’s bulletproof yet. Gradual load progression and maybe one more short maintenance pulse of TB-500 could help lock in the recovery for good.

Overall, this is one of those comeback stories that shows why peptides deserve more attention in sports medicine. From sidelined and frustrated to training legs again pain-free

it’s the kind of win every lifter with chronic pain dreams about…. Thanks for sharing it!!

Shark!
I’ve noticed a skin rash on my wrist—especially on the inner side—after using BPC-157, possibly related to the bacteriostatic water as well. Whenever I stop the peptide, the rash disappears within about 1.5 days. When I resume, it reappears in roughly the same time frame. This is the only negative effect I’ve experienced so far, and I’m willing to accept it because the treatment has significantly reduced my pain.
 
I’ve noticed a skin rash on my wrist—especially on the inner side—after using BPC-157, possibly related to the bacteriostatic water as well. Whenever I stop the peptide, the rash disappears within about 1.5 days. When I resume, it reappears in roughly the same time frame. This is the only negative effect I’ve experienced so far, and I’m willing to accept it because the treatment has significantly reduced my pain.
Well, under that is a minor issue compared with the results you have got!!

Please, do not hesitate reaching us once you feel ready to change your strategy from a healing to a mass growing machine :cool:
 
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Have you checked why you have knee pain ?

If you say it's since you've started running :
  • Do a analysis of your walk and buy the perfect shoes for you (and yes good running shoes are over 150€)
  • Start "running the right way" many people are using the "wrong running technique"
  • Check your hips , most of the time hip problems are causing knee pain

I had exactly the same years ago and my main problem was hips and wrong shoes .
 
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