Expert Answered Is oral sublingual the best way? How to take it?

[Lugano]

Many people take oral steroids sublingually because it’s said to take effect faster pre-workout and is also healthier for the liver.
Can Driada’s oral steroids also be taken sublingually?
I tried taking Anavaros (Oxandrolone) and Anadrolus (Oxymetholone) sublingually by crushing the white tablets as finely as possible and then placing them under my tongue. But even after 15 minutes, almost the entire tablet was still clumped together under my tongue and mixed with saliva. Am I doing something wrong?

 

[Davy Tenebrae]

Many people take oral steroids sublingually because it’s said to take effect faster pre-workout and is also healthier for the liver.
Can Driada’s oral steroids also be taken sublingually?
I tried taking Anavaros (Oxandrolone) and Anadrolus (Oxymetholone) sublingually by crushing the white tablets as finely as possible and then placing them under my tongue. But even after 15 minutes, almost the entire tablet was still clumped together under my tongue and mixed with saliva. Am I doing something wrong?

I used to do this with Stano, Anadrolus and Cialyn 20mg, you first have to drink plenty of water o liquids in general, then after some minutes proceed to crush the tab really fine and then put it under your tongue and wait a good 15-20 minutes and you should be good, this way of administration is good for bypassing liver metabolism but it will still affect it

 

[Lugano]

How much faster does sublingual administration work compared to oral administration? And is the efffect the same?
Is there any additive you can mix with the tablets to make them dissolve extremely quickly?

I usually just take my orals 2 hours pre workout.

 

[Davy Tenebrae]

How much faster does sublingual administration work compared to oral administration? And is the efffect the same?
Is there any additive you can mix with the tablets to make them dissolve extremely quickly?

I usually just take my orals 2 hours pre workout.

anectotally i say almost 30 mins for oral aas, and yes the effect is the same as you would expect, i found myself very comfortable just waiting and then drinking some coffee pre workout to swallow down the remainings

 

[Lugano]

Is it possible to speed up the absorption when taken orally? I usually work out in the morning, and it's very inconvenient to always have to wait two hours after taking it before I can go to the gym.

 

[epicsteff]

Is it possible to speed up the absorption when taken orally? I usually work out in the morning, and it's very inconvenient to always have to wait two hours after taking it before I can go to the gym.

You'll probably absorb it fastest on an empty stomach and sublingually. After that, it's best to wait about 30-60 minutes before eating. Of course, it's hard to time that if you're planning to work out soon. So you should probably eat some fast-digesting carbs and use a maltodextrin or cluster dextrin intra-workout supplement.

A little biology geek fact: When taken sublingually, the active ingredient dissolves in saliva and can diffuse through the mucous membrane under the tongue due to a concentration gradient. However, no one can tell you exactly how quickly or effectively this happens with VAR. Anecdotally, though, people report faster absorption when oral AAS are taken sublingually.
If a lot of saliva builds up after a while, I’d just swallow it. As time goes on and the concentration of the active ingredient in the saliva decreases, the driving force for diffusion tends to diminish. However, you can’t really tell just by the amount of saliva how much of the active ingredient has already been absorbed.
If the remainder is then swallowed, that portion is absorbed through the gastrointestinal tract. In practice, this means that you do a hybrid application method, the intake is partly sublingual and partly oral, which is fine. I’s probably still faster-acting than taking it exclusively orally.

 

[epicsteff]

You'll probably absorb it fastest on an empty stomach and sublingually. After that, it's best to wait about 30-60 minutes before eating. Of course, it's hard to time that if you're planning to work out soon. So you should probably eat some fast-digesting carbs and use a maltodextrin or cluster dextrin intra-workout supplement.

A little biology geek fact: When taken sublingually, the active ingredient dissolves in saliva and can diffuse through the mucous membrane under the tongue due to a concentration gradient. However, no one can tell you exactly how quickly or effectively this happens with VAR. Anecdotally, though, people report faster absorption when oral AAS are taken sublingually.
If a lot of saliva builds up after a while, I’d just swallow it. As time goes on and the concentration of the active ingredient in the saliva decreases, the driving force for diffusion tends to diminish. However, you can’t really tell just by the amount of saliva how much of the active ingredient has already been absorbed.
If the remainder is then swallowed, that portion is absorbed through the gastrointestinal tract. In practice, this means that you do a hybrid application method, the intake is partly sublingual and partly oral, which is fine. I’s probably still faster-acting than taking it exclusively orally.

As @Davy Tenebrae already mentioned, many people take caffeine with oral steroids and say they feel the effects faster or more strongly. However, this could simply be caused, at least partly, by the stimulating effects of caffeine.

For oxandrolone, there is also a small amount of experimental evidence that caffeine may affect how the drug is absorbed or processed by the body. In one study with only a single person, much higher amounts of oxandrolone and its metabolite were found in the urine when caffeine was taken at the same time. This may suggest increased bioavailability or changed absorption. However, the study is not very reliable because it involved only one person, did not provide useful blood level data, and does not prove that oxandrolone works faster or has a stronger anabolic effect.

So my advice would be: Take your var sublingual, wait 5-10min minutes before swallowing your salvia down with an espresso and wait another 30min before you eat your first meal. Ideally you eat fast-digested carbs + take an intra with malto into your workout.

 

[Lugano]

But if I take only half the tablet sublingually and swallow the other half, and then go to the gym an hour later, I’ll only have the effects of half the tablet in my bloodstream.
Do you think it would help if I ground the tablets into a fine powder and stirred it into my coffee? What about grapefruit juice? I’ve heard that’s supposed to enhance the effects, too.

 

[epicsteff]

But if I take only half the tablet sublingually and swallow the other half, and then go to the gym an hour later, I’ll only have the effects of half the tablet in my bloodstream.
Do you think it would help if I ground the tablets into a fine powder and stirred it into my coffee? What about grapefruit juice? I’ve heard that’s supposed to enhance the effects, too.

Yeah I know, but it's the best option you got, it's not really possible to take 100% sublingually, because the tablets are not made for that.

I don't really see an advantage in stirring it into your coffee, because then, you just take 100% oral, no matter how much you ground the tablet....

But you're right with the grapefruit juice thing, I heard about that in a VigorousSteve video and it seems like it really increases the bioavailability, by blocking a specific enzyme in your gut and liver.

So the best you can do is, to leave the var under your tongue for a few minutes, then swallow the remaining salvia together with grapefruit juice and after that you should take 300mg of caffeine (the dose from the study; only take 300mg if you can handle that).

 

[Lugano]

What do you guys think of the method where you crush the pill inside of a syringe with some water and the pill gets liquified. I could imagine that "drinking" the tablet makes it get absorbed faster than swallowing a solid tablet

 

[Donvitosharkone]

What do you guys think of the method where you crush the pill inside of a syringe with some water and the pill gets liquified. I could imagine that "drinking" the tablet makes it get absorbed faster than swallowing a solid tablet

I’ve been reading this thread, and I think we’re overcomplicating something that needs a little clarification.

First, crushing a tablet doesn’t automatically make it sublingual. Tablets are formulated for a specific route of administration. Driada’s Anavaros and Anadrolus are conventional oral tablets, not formulations designed for absorption under the tongue.

Second, dissolving a tablet and absorbing the active ingredient are two completely different things. The powder disappearing under your tongue doesn’t prove the steroid has entered your bloodstream. Some of it may be absorbed through the oral mucosa, but much of it can simply end up being swallowed.

And here’s the important part: sublingual administration doesn’t automatically protect your liver. Even if some of the drug bypasses first-pass metabolism, it still reaches the liver through systemic circulation. The liver toxicity associated with 17-alpha-alkylated steroids doesn’t magically disappear.

Regarding the other suggestions:

Grapefruit juice can interfere with drug-metabolizing enzymes, but that doesn’t establish a predictable benefit for oxandrolone or oxymetholone. It can also create dangerous interactions with other medications.

Caffeine might make you feel more stimulated before training, but that doesn’t prove the steroid is being absorbed faster or working better. The single-person study mentioned earlier is nowhere near enough evidence to recommend combining them for this purpose.

And crushing tablets into coffee or dissolving them in a syringe? Neither guarantees faster absorption or improved bioavailability.

My point is simple, mate: we have no reliable human pharmacokinetic data demonstrating that crushing these particular tablets and taking them sublingually provides a meaningful advantage over swallowing them normally.

Also, oral anabolic steroids aren’t conventional pre-workout stimulants. Chasing a faster peak doesn’t necessarily translate into better muscle growth or performance.

I would suggest sticking to the intended oral administration rather than experimenting with absorption tricks that haven’t been properly studied.

Sometimes the smartest bodybuilding decision is simply to stop complicating things.

Shark