Ho iniziato il mio primo ciclo con testosterone enantato 300 mg a settimana, assunto due volte a settimana, una la domenica e una il mercoledì, e sto prendendo dimetazina per supportare la funzionalità epatica. Dopo un mese, gli esami mostrano che i miei enzimi epatici sono leggermente elevati, ma va bene. I miei livelli non sono troppo alti. Ciò che mi preoccupa è il mio beta-estradiolo, che è a 214 con un intervallo massimo di 47. La mia prolattina è a 28 con un intervallo massimo di 15. LH e FSH sono a 0,3 con un intervallo minimo di 1,5. Il mio consiglio è questo:
Vale la pena assumere un inibitore dell'aromatasi, e quale? Sto prendendo anastrozolo, exemestane, tamoxifene ed enclomifene come trattamento post-ciclo, ma non so quale iniziare a prendere. È importante precisare che finora, a un mese e mezzo dall'inizio del ciclo, non ho avuto effetti collaterali visibili. I miei capezzoli sono ancora eretti, ma non so se si tratti dell'inizio di ginecomastia. A me non sembra. Per il resto va tutto bene.
Grazie infinite per i tuoi preziosi consigli.
Hi Mr_Hybrid
First of all,
don’t panic!! Looking at your bloodwork as a whole, there are actually more good signs than bad ones.
LH and FSH being close to zero is exactly what we’d expect while you’re on exogenous testosterone, so that part isn’t concerning. Your total and free testosterone are clearly in the expected supraphysiological range for 300 mg/week.
The two values that deserve attention are estradiol (214 pg/mL) and prolactin (28 ng/mL). Estradiol is significantly elevated, but numbers alone don’t dictate treatment. The real question is:
how do you feel? If you’re NOT experiencing nipple tenderness, itching, breast tissue growth, excessive water retention, emotional instability or uncontrolled blood pressure, I
wouldn’t rush to crash your estrogen. Estrogen is not the enemy; it’s essential for libido, joints, cardiovascular health and muscle growth.
That said, with an E2 over 200, I personally wouldn’t just ignore it either. I’d introduce a low dose of an aromatase inhibitor rather than trying to force estradiol into the normal range overnight. Small adjustments, then repeat bloodwork in 2-3 weeks. It’s much easier to lower estrogen gradually than to recover from crashing it.
Your prolactin is only mildly elevated from my perspective. High estradiol itself can contribute to that, so I would address estrogen first and then repeat prolactin before thinking about medications specifically targeting prolactin.
One thing I would not do is start Tamoxifen, Enclomiphene and an AI all together. They all have different purposes. Tamoxifen and Enclomiphene are PCT drugs, not compounds to manage estrogen during an active testosterone cycle. During the cycle, if intervention is needed, the AI is the appropriate tool. Save your PCT protocol for when the cycle actually ends.
Overall, I think you’re in a much better position than you believe. Your hormones are behaving exactly as expected for someone on testosterone, you’ve had no meaningful side effects after six weeks, and your bloodwork gives you plenty of room to make calm, measured decisions instead of reacting to one number.
Keep monitoring blood pressure, get another set of labs in a few weeks after any adjustment, and keep us updated. You’re asking the right questions to the right friends!! and that’s already putting you ahead of most first-time users.
Shark
